Jin why jennifer

Class is based on a final group project. The project is pretty difficult. The class is expected to know how to do a lot from the start even though we are just undergrad students. Making full stack applications in 15 weeks with languages you've never used before whilst juggling other classes work is really difficult.

Apr 29th, Jin is a very nice lady; however, she still has ways to improve in terms of her teaching. I understand she is relatively new considering it was her first semester, but I basically learned almost nothing from her lectures.

The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of breast cancer in Latinas and identify a genome-wide significant risk variant, located 5' of the Estrogen Receptor 1 gene ESR1; 6q25 region. The minor allele for this variant is strongly protective rs odds ratio OR 0. The association is stronger for oestrogen receptor-negative disease OR 0. These results highlight the importance of conducting research in diverse populations.

Here we report a finding of an association between genetic ancestry and adjusted PMD. We selected self-identified Caucasian women in the California Pacific Medical Center Research Institute Cohort whose screening mammograms placed them in the top or bottom quintiles of age-adjusted and body mass index-adjusted PMD.

Our final dataset included women with the highest adjusted PMD and with the lowest genotyped on the Illumina 1 M platform. Principal component analysis PCA and identity-by-descent analyses allowed us to infer the women's genetic ancestry and correlate it with adjusted PMD.

Using multivariate regression to adjust for epidemiologic factors associated with PMD, including age at parity and use of postmenopausal hormone therapy, did not attenuate the association. Women of Ashkenazi Jewish ancestry, based on genetic analysis, are more likely to have high age-adjusted and body mass index-adjusted PMD. Ashkenazi Jews may have a unique set of genetic variants or environmental risk factors that increase mammographic density.

The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific.

We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC. Population geneticists often study small numbers of carefully chosen loci, but it has become possible to obtain orders of magnitude for more data from overlaps of genome sequences. Here, we generate tens of millions of base pairs of multiple sequence alignments from combinations of three western chimpanzees, three central chimpanzees, an eastern chimpanzee, a bonobo, a human, an orangutan, and a macaque.

Analysis provides a more precise understanding of demographic history than was previously available. We show that bonobos and common chimpanzees were separated approximately 1,, years ago, western and other common chimpanzees approximately , years ago, and eastern and central chimpanzees at least 50, years ago. We infer that the central chimpanzee population size increased by at least a factor of 4 since its separation from western chimpanzees, while the western chimpanzee effective population size decreased.

Surprisingly, in about one percent of the genome, the genetic relationships between humans, chimpanzees, and bonobos appear to be different from the species relationships. We used PCR-based resequencing to confirm 11 regions where chimpanzees and bonobos are not most closely related. Study of such loci should provide information about the period of time million years ago when the ancestors of humans separated from those of the chimpanzees.

Tab Menu. Clinical Focus Oncology. Member, Stanford Cancer Institute. Additional Info Mail Code: Current Research and Scholarly Interests My research is on the translational application of next-generation sequencing technologies to breast cancer care: 1 the value of hereditary cancer genetic panel testing in clinical practice, 2 the mechanisms by which inherited genetic variants lead to breast cancer development, and 3 the analysis of somatic tumor sequencing data to inform understanding of breast tumorigenesis, metastasis, and development of resistance in response to therapeutics.

Abstract Treatment and monitoring options for patients with metastatic breast cancer MBC are increasing, but little is known about variability in care. Abstract The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data. Abstract Most population-based cancer databases lack information on metastatic recurrence. Abstract Anthracyclines are a highly effective component of curative breast cancer chemotherapy but are associated with substantial morbidity1,2.

Abstract Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Abstract Electronic medical records EMRs and population-based cancer registries contain information on cancer outcomes and treatment, yet rarely capture information on the timing of metastatic cancer recurrence, which is essential to understand cancer survival outcomes.

Abstract Metastatic breast cancer MBC treatment has changed substantially over time, but we do not know whether survival post-metastasis has improved at the population level. Do leaders who espouse a learning mindset but enact a fixed mindset elicit less trust and more stereotype threat among marginalized groups? Skip to main content.

Recent Courses. View more. Recent Products. Kim J. Busting the model minority myth: How positive attitudes toward Asians impact perceptions of subtle workplace discrimination experienced by Asians. Congruence between self-affirmation and self-construal eliminates the MBA gender performance gap. Recent Projects.